Frankincense is extracted from boswellia and contains boswellic acids which accounts for its activity.
Studies show that boswellic acid inhibits 5-lipoxygenase selectively and has anti-inflammatory, antiarthritic, and anti-proliferative effects against cancer cells.. It also inhibits the signaling pathways of the transcription factor, nuclear factor (NF-KappaB), in macrophages in mouse model of psoriasis, markedly decreasing the production of the pro-inflammatory key cytokine tumor necrosis factor (TNF-alpha). Research also indicates that it induces p21 expression through a p53-independent pathway and causes apoptosis in glioma and leukemia cells. In addition, a Boswellia extract induced apoptosis in a cervical cancer by inducing endoplasmic reticulum (ER) stress.
This Boswellia extract we prefer is standardized to 65% boswellic acids, each tablet of which contains 307 mg of the extract. Taken three times a day or more as directed by a qualified health practitioner, it provides the researched clinical dose used to support joint health and mobility and other health issues.
Relevant recent research:
Frankincense ( rǔ xiāng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. J Tradit Complement Med. 2013 Oct;3(4):221-6.
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M. Clin Pharmacokinet. 2011 Jun;50(6):349-69.
Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Ammon HP. Phytomedicine. 2010 Sep;17(11):862-7.
Recommended dose is one 307mg tablet three times a day.
One bottle provides 20 days supply at the recommeded dose.
Dr. Chang: I use this at 1-2 tablets three times a day, frequently in combination with curcumin extracts as an anti-inflammatory in auto-immune, cancer or arthritis cases.