Methylcobalamin is the form of vitamin B12 that is active in the central nervous system. Methylcobalamin exerts its neuroprotective effects through enhanced methylation, acceleration of nerve cell growth, or its ability to maintain already healthy homocysteine levels. For methylcobalamin to be available to the brain, it should be allowed to dissolve in the mouth. Methyl B12 protects nervous system tissue and brain cells from toxins. Methylcobalamin should be considered in the treatment of neurological disease. Based on its mechanism of action, it could be effective in slowing the progression of neurodegenerative diseases such as Parkinson's, Alzheimers, muscular dystrophy. It has also been studied to treat peripheral neuropathies.
L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline. McCaddon A, Hudson PR. CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5.
Mecobalamin. Zhang YF, Ning G. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64.
Dose: 5mg lozenges, 2-3 lozenges up to 5 times a day to dissolve under the tongue, as directed by a qualified health professional. One bottle contains 60 lozenges.